5-Amino-1MQ (50mg)

5-Amino-1MQ (5-Amino-1-methylquinolinium) is a small-molecule selective inhibitor of an enzyme called nicotinamide N-methyltransferase (NNMT). NNMT consumes nicotinamide — the precursor your body uses to make NAD+ — and a methyl-donor molecule called SAM. Its activity is elevated in the fat tissue of obese subjects in published preclinical research, which is why it has become a focus of research into adipose biology and the NAD+ salvage pathway.

It selectively inhibits NNMT in tissues where the enzyme is overactive — most notably white adipose tissue in preclinical obese models. By blocking NNMT, less nicotinamide gets methylated and excreted, more remains available for the NAD+ salvage pathway, and the methylation balance of the cell shifts. Published rodent studies report this is associated with reduced adipocyte size and reduced fat mass, without changes in food intake.

NAD+ and NMN add to the NAD+ pool directly (NAD+) or via a precursor (NMN). 5-Amino-1MQ works upstream — it slows down the enzyme that consumes the building blocks, so more nicotinamide stays available to feed the NAD+ salvage pathway naturally. Some researchers explore 5-Amino-1MQ alongside NAD+ or NMN protocols; others use it as a standalone tool to probe NNMT-specific biology in adipose tissue.

The compound was profiled by a research group at the University of Texas Southwestern Medical Center and has been characterised in published in-vitro and rodent work. Studies in diet-induced obese mice have reported reductions in white-adipose-tissue mass, smaller adipocytes, and improved metabolic markers without changes in food intake. There are no published human clinical trials in the public literature at the time of writing — it remains an investigational research compound.

No. 5-Amino-1MQ is a small molecule — a methylated quinoline derivative — not a peptide. It is handled the same way as the peptides we stock, though: supplied as a powder for reconstitution with bacteriostatic (BAC) water and subcutaneous injection.

Store the unmixed powder in a cool, dry place away from light and moisture — refrigeration, or freezing at -20°C, is recommended for longest shelf life. Once reconstituted with bacteriostatic water, refrigerate the vial at 2–8°C and use within several weeks; do not freeze the reconstituted solution.

5-Amino-1MQ (50mg) is available through Aussie Peptides with fast domestic shipping to all Australian states and territories. Every vial is dispatched from within Australia — no customs delays. Each batch undergoes third-party analysis and the Certificate of Analysis is available to view in our CoA Library.

5-Amino-1MQ (50mg) is currently in stock at Aussie Peptides and available for domestic dispatch across Australia. 5-Amino-1MQ (50mg) is priced at $119.99 per vial at Aussie Peptides. All orders ship domestically within Australia, and batch CoAs are available in our CoA library.